Clipboard, Search History, and several other advanced features are temporarily unavailable. Damage to skin was calculated by comparing the water absorption rates of skin before and after exposure to the test compound. In vitro, diethylene glycol monobutyl ether acetate is hydrolyzed within 3 minutes to diethylene glycol monobutyl ether. This site needs JavaScript to work properly. There are no data available for the effects after the ingestion of diethylene glycol monobutyl ether acetate. DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. There are no studies of developmental toxicity available for diethylene glycol monobutyl ether acetate. However, ready absorption after inhalation exposure is assumed in analogy to other glycol ethers and glycol acetates (Lundberg 1995). They react with oxoacids and carboxylic acids to … DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Candidate List DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Annex XIV List 15.1.2. Marek EM, Koslitz S, Weiss T, Fartasch M, Schlüter G, Käfferlein HU, Brüning T. Arch Toxicol. 1994 May;13(5):325-35. doi: 10.1177/096032719401300508. Summary – Ethylene Glycol vs Diethylene Glycol Both ethylene glycol and diethylene glycol are produced from same starting material; ethylene. COVID-19 is an emerging, rapidly evolving situation. In an inadequately documented study from 1944, diethylene glycol monobutyl ether acetate was applied to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. Packaging 1, 2.5 L in glass bottle eCollection 2018. Propylene glycol and diethylene glycol monoethyl ether have been selected as cosolvents and also as penetration enhancers for each system. Epub 2003 Jun 19. Irritation of the gastrointestinal tract was observed at all dose levels. Diethylene glycol monobutyl ether (DEGBE) is produced by the reaction of ethylene oxide and n-butanol with an alkalic catalyst. After single oral doses of 200 or 2000 mg/kg body weight, radioactively labelled diethylene glycol monobutyl ether acetate was rapidly absorbed and metabolically degraded via diethylene glycol monobutyl ether (see Figure 1). Rinse skin with plenty of water or shower. New toxicity data for the propylene glycol ethers - a commitment to public health and safety. 2005 Mar 28;156(1):181-8. doi: 10.1016/j.toxlet.2003.09.023. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. Please enable it to take advantage of the complete set of features! HHS Background: Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. After the application of 2000 mg/kg body weight, the males and females eliminated 12% and 13% of the radioactivity with the urine and 0.4% and 1.4% with the faeces, respectively. The difference between ethylene glycol and diethylene glycol is that an ethylene glycol molecule is an individual molecule whereas diethylene glycol molecule is formed by the combination of two ethylene glycol molecules via an ether bond. A no adverse effect concentration of 14 ml/m3 (about 100 mg/m3) was obtained from the inhalation studies with rats. Several studies were carried out to investigate the effects of diethylene glycol monobutyl ether on offspring after ingestion and dermal application, but no evidence of prenatal or postnatal toxicity was found up to the highest doses tested: in rats, after the administration of diethylene glycol monobutyl ether with the diet on days 1 to 21 of gestation in doses of up to 633 mg/kg body weight and day with prenatal and postnatal examinations and after 13‐week dermal application of 2000 mg/kg body weight and day; in mice, after the oral administration of up to 2050 mg/kg body weight and day on days 6 to 13 of gestation, and in rabbits after the dermal application of up to 1000 mg/kg body weight and day on days 7 to 18 of gestation and prenatal examination (see There are no data available for the developmental toxicity of diethylene glycol monobutyl ether acetate. Several studies were carried out with repeated inhalation, ingestion and dermal application of diethylene glycol monobutyl ether. Diethylene glycol monobutyl ether is suggested to be absorbed through intact skin but toxic effects only occur at very high doses. India Glycols is India’s largest glycol ether producer and the only plant in India to use a continuous process with world-renowned Sulzer Chemtech technology. Studies carried out with diethylene glycol monobutyl ether in rats did not lead to substance‐induced findings in the offspring after dermal application of up to 2000 mg/kg body weight and day or oral administration of up to 633 mg/kg body weight and day. Ethereal. The rate of absorption of the test compound across Diethylene Glycol Monobutyl Ether Acetate Market is a professional and a complete report focusing on primary and secondary drivers, market share, competitor analysis, leading segments and geographical analysis. In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate has not been designated with “Sa” or “Sh”. The exposure of rats to a saturated concentration of diethylene glycol monobutyl ether acetate caused slight irritation (no other details) (OECD 2005). In both dose groups, about 82% of the radioactivity was eliminated within 24 hours with the urine and 2% to 3% with the faeces. Clinical toxicology of ethylene glycol monoalkyl ethers. Methods: What is Diethylene Glycol Monobutyl Ether? EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. The course of ethylene glycol toxicity is classically divided into three broad overlapping categories of adverse health effects. Metabolites of diethylene glycol monobutyl ether acetate. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. 11 octanol/water partition coefficient. 2004 Feb;77(2):85-9. doi: 10.1007/s00420-003-0455-4. With a rate of 162±43.3 µg/cm2 and hour, the flux of a saturated aqueous solution (6.65%) was higher than that of the undiluted substance (Venier et al. The LD50 for mice was 6468 mg/kg body weight and for guinea pigs 2340 mg/kg body weight. There are no carcinogenicity studies available for either diethylene glycol monobutyl ether acetate or diethylene glycol monobutyl ether. Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions. On the basis of the available data and by analogy with diethylene glycol monobutyl ether, dermal exposure is assumed to pose no additional risk. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use, Toxicology of diethylene glycol butyl ether 2. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 2018 Oct 31;13(10):e0205458. 2004). In a 13‐week study in which diethylene glycol monobutyl ether was administered to rats with the drinking water, no histopathological changes to the sexual organs were detected up to the highest dose used of 1000 mg/kg body weight and day (see It is under evaluation by the European Union through French research, for its safety where it is absorbed into the skin. DEG is used as a component of multiple different products including antifreeze preparations, cosmetics, lubricants, brake fluids, wallpaper strippers, heating/cooling fuel and as a plasticizer. Further unidentified metabolites were found (Boatman et al. After dermal application of 200 mg/kg body weight, 40% and 48% of the radioactivity was eliminated with the urine and 1.45% and 3.15% with the faeces by the males and females, respectively. • As a structural component of various liquid crystals. Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin. Working off-campus? • As a cosurfactant in the formation of microemulsions. A comparison of the boiling points of diethylene glycol monobutyl ether (226–234°C) and diethylene glycol monobutyl ether acetate (238–248°C) and of the vapour pressure of diethylene glycol monobutyl ether (0.027 hPa) with that of diethylene glycol monobutyl ether acetate (0.013–0.05 hPa) shows that the two substances are of similar volatility. In vitro percutaneous absorption of cobalt. In the case of solvents with high dermal absorption, the air concentration is no longer a sufficient measure of the total exposure to workers, and therefore merely respecting threshold limit values (TLVs) in the air is not necessarily enough to protect them. Diethylene glycol (DEG) is a clear, colorless, odorless liquid with a sweet taste, and is an excellent solvent for water-insoluble chemicals and drugs. In vitro studies yielded a mean permeability constant of 1.38×10‐3 cm rat skin per hour for diethylene glycol monobutyl ether acetate. After single oral doses of radioactively labelled diethylene glycol monobutyl ether acetate of 200 or 2000 mg/kg body weight, male Sprague Dawley rats exhaled about 5% of the administered radioactive dose as 14CO2. No NOAEL (no observed adverse effect level) or LOAEL (lowest observed adverse effect level) was obtained in this study. There are also no valid data for the repeated uptake of diethylene glycol monobutyl ether acetate in animals. Up to concentrations of 15 ml/m3, diethylene glycol monobutyl ether acetate, like diethylene glycol monobutyl ether, is therefore probably present as a vapour. Venier M, Adami G, Larese F, Maina G, Renzi N. Toxicol In Vitro. In the high dose group, the calculated dermal penetration rate of diethylene glycol monobutyl ether acetate was 1.58 and 1.28 mg/cm2 and hour in male and female rats, respectively. The presence of acetone in the solution caused a reduction in lag time and an increase in permeation rate, higher for EGMEE, lower for EGDEE, indicating the enhancing effect of this mixture of solvents. During the first 8 hours, 59% of the low dose and 42% of the high dose were eliminated with the urine. OPINION ON DIETHYLENE GLYCOL MONOBUTYL ETHER (DEGBE) 9 chamber and the appearance of radioactivity was measured in the receptor chamber. Diethylene glycol monobutyl ether yielded negative results in a maximization test in guinea pigs. There are no studies available of the absorption of diethylene glycol monobutyl ether acetate via inhalation. 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